NANOS1 Q8WY41

Nanos同源物1 (NOS-1) (EC_Rep1a)

功能描述

可能作为翻译抑制因子，通过与PUM2形成复合物并结合mRNA靶点的3'-UTR，从而调节特定mRNA的翻译。能够干扰E-cadherin的促粘附和抗侵袭功能。上调MMP14的产生以促进肿瘤细胞侵袭。 {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}。

组织特异性

Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.

亚细胞定位

Cytoplasm, perinuclear region