伏隔核相关蛋白 1 (NAC-1) (含BTB/POZ结构域蛋白 14B)
伏隔核相关蛋白 1 (NAC-1) (含BTB/POZ结构域蛋白 14B)
Q96RE7功能描述
作为转录抑制因子发挥作用。似乎通过招募HDAC3和HDAC4在神经元细胞中作为转录共抑制因子发挥作用。促进肿瘤进展，以及肿瘤细胞增殖和存活。这可能至少部分通过抑制GADD45GIP1的转录活性来介导。对于将蛋白酶体从细胞核招募到细胞质和树突棘是必需的。 {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}。
组织特异性
Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
亚细胞定位
Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation.
关键词