N-α-乙酰转移酶15，NatA辅助亚基 (胃癌抗原Ga19) (N端乙酰转移酶) (NMDA受体调节蛋白1) (Protein tubedown-1) (Tbdn100)
N-α-乙酰转移酶15，NatA辅助亚基 (胃癌抗原Ga19) (N端乙酰转移酶) (NMDA受体调节蛋白1) (Protein tubedown-1) (Tbdn100)
Q9BXJ9功能描述
N末端乙酰转移酶复合物的辅助亚基，该复合物具有α（N末端）乙酰转移酶（NAT）活性 (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062)。这种NAT活性可能对血管、造血和神经的生长发育很重要 (PubMed:15496142)。控制成人眼内皮细胞视网膜新生血管形成所必需的 (PubMed:11687548)。与XRCC6和XRCC5 (Ku80)形成复合物，上调骨钙蛋白启动子的转录 (PubMed:12145306)。 {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}。
组织特异性
Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.
亚细胞定位
Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
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