MYO6 Q9UM54

非传统肌球蛋白-VI (非传统肌球蛋白-6)

功能描述

肌球蛋白是具有ATPase活性的肌动蛋白基础马达分子 (By similarity)。非典型肌球蛋白参与细胞内运动 (By similarity)。Myosin 6是一种反向马达蛋白，朝向肌动蛋白微丝的负端移动 (PubMed:10519557)。由于ATP结合力弱，其肌动蛋白激活的ADP释放速率较慢 (By similarity)。在多种细胞内过程中发挥作用，如囊泡膜运输和细胞迁移 (By similarity)。通过p53依赖性促生存通路维持高尔基体的结构完整性 (PubMed:16507995)。似乎参与极化上皮细胞中网格蛋白介导的内吞作用的极早期步骤 (PubMed:11447109)。与TOM1一起，介导内吞货物递送至自噬体，从而促进自噬体成熟并驱动与溶酶体的融合 (PubMed:23023224)。将TOM1与自噬受体连接，例如TAX1BP1；CALCOCO2/NDP52和OPTN (PubMed:31371777)。可能作为F-actin动力学的调节因子 (By similarity)。作为DISP复合物的一部分，可能调节septins与肌动蛋白的结合，从而调节肌动蛋白细胞骨架 (PubMed:29467281)。可能在将DAB2从细胞质膜转运至特定细胞靶点的过程中发挥作用 (By similarity)。可能在神经突的延伸和网络组织中发挥作用 (By similarity)。维持内耳毛细胞的结构完整性所必需 (By similarity)。CLIC5和RDX在静纤毛基部正确定位所必需 (By similarity)。调节RNA聚合酶II依赖性转录 (PubMed:16949370)。 {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}.

组织特异性

Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells.

亚细胞定位

Golgi apparatus, trans-Golgi network membrane