MYO18B Q8IUG5

非典型肌球蛋白-XVIIIb

功能描述

位于细胞质时，可能参与肌肉细胞的胞内运输，而进入细胞核时，可能参与肌肉特异性基因的调控。可能在肿瘤发生和进展的控制中发挥作用；在肺癌细胞中恢复MYO18B表达可抑制非锚定依赖性生长。

组织特异性

Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.

亚细胞定位

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.