MYCNOS P40205

N-cym蛋白 (N-myc反向链)

功能描述

通过抑制GSK3B介导的MYCN磷酸化，调节神经母细胞瘤细胞中MYCN的稳定性。通过促进GSK3B在'Ser-9'位点的磷酸化来抑制GSK3B活性 (PubMed:24391509)。 {ECO:0000269|PubMed:24391509}.

组织特异性

Expressed in the neuronal cells of the cerebrum and cerebellum, spermatocytes of the testis, pancreatic cells and also the heart. Expressed in both primary and metastatic neuroblastomas and in thyroid tumors (at protein level). Expression is associated with poor prognosis in neuroblastoma. Expressed in the fetal brain, lung, liver and kidney at varying low levels.

亚细胞定位

Cytoplasm