MVP Q14764

主要穹隆蛋白 (MVP) (肺耐药相关蛋白)

功能描述

正常vault结构所必需。Vault是多亚基结构，可能作为信号转导相关protein的支架。Vault也可能在核质运输中发挥作用。下调IFNG介导的STAT1信号传导及随后的JAK激活。下调SRC活性及通过MAP激酶的信号传导。 {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}。

组织特异性

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

亚细胞定位

Cytoplasm