MUC6 Q6W4X9

黏蛋白-6 (MUC-6) (胃黏蛋白-6)

功能描述

可能提供一种调节保护性粘液层组成的机制，该机制与酸分泌或管腔内细菌及有害物质的存在有关。在上皮表面的细胞保护中发挥重要作用，并在多种癌症中作为肿瘤标志物。可能在上皮器官发生中发挥作用。 {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}。

组织特异性

Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.

亚细胞定位

Secreted.