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MUC5AC P98088

黏蛋白-5AC (MUC-5AC) (胃黏蛋白) (主要气道糖蛋白) (黏蛋白-5亚型AC,气管支气管) (气管支气管黏蛋白) (TBM)

蛋白质信息 (UniProt)

黏蛋白-5AC (MUC-5AC) (胃黏蛋白) (主要气道糖蛋白) (黏蛋白-5亚型AC,气管支气管) (气管支气管黏蛋白) (TBM)

P98088

功能描述

胃和呼吸道上皮的凝胶形成糖蛋白,通过结合吸入的微生物和颗粒(随后被粘液纤毛系统清除),保护粘膜免受感染和化学损伤 (PubMed:14535999, PubMed:14718370)。在胃上皮、Barrett食管以及十二指肠胃化生 (GMD) 中与幽门螺杆菌相互作用 (PubMed:14535999)。 {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}。

组织特异性

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.

亚细胞定位

Secreted

关键词

3D-structure Copper Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Proteomics identification Reference proteome Repeat Secreted