微管相关肿瘤抑制因子1 (AT2受体结合蛋白) (血管紧张素II 2型受体相互作用蛋白) (线粒体肿瘤抑制因子1)
微管相关肿瘤抑制因子1 (AT2受体结合蛋白) (血管紧张素II 2型受体相互作用蛋白) (线粒体肿瘤抑制因子1)
Q9ULD2功能描述
与AGTR2协作抑制ERK2激活和细胞增殖。可能是AGTR2细胞表面表达所必需的。与PTPN6一起，在血管紧张素-II刺激下诱导UBE2V2表达。Isoform 1抑制乳腺癌细胞增殖，通过延长中期延缓有丝分裂进程，并减少肿瘤生长。{ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}。
组织特异性
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
亚细胞定位
Mitochondrion
关键词