MTDH Q86UE4

LYRIC蛋白 (3D3/LYRIC) (星形胶质细胞升高基因-1蛋白) (AEG-1) (富含赖氨酸CEACAM1共分离蛋白) (Metadherin) (转移粘附蛋白)

功能描述

异位表达时下调SLC1A2/EAAT2启动子活性。激活核因子kappa-B (NF-kappa-B)转录因子。促进永生化黑色素细胞和星形胶质细胞的锚定非依赖性生长，这是肿瘤细胞扩增的关键组成部分。促进肺转移，并对骨转移和脑转移也有影响，可能是通过增强肿瘤细胞在靶器官内皮的定植。诱导化疗耐药。 {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}。

组织特异性

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

亚细胞定位

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane