髓鞘蛋白零样蛋白1 (蛋白零相关)
髓鞘蛋白零样蛋白1 (蛋白零相关)
O95297功能描述
细胞表面受体，参与信号转导过程。募集PTPN11/SHP-2至细胞膜，并且是PTPN11/SHP-2的推定底物。是伴刀豆球蛋白-A (ConA)的主要受体，参与ConA诱导的细胞信号传导，该过程可能包括Src家族酪氨酸-蛋白激酶。Isoform 3似乎具有显性负调控作用；它阻断ConA诱导的MPZL1酪氨酸磷酸化。Isoform 1，而非isoform 2和isoform 3，可能参与整合素介导的细胞运动调节。 {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}。
组织特异性
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.
亚细胞定位
Membrane
关键词