MPDZ O75970

多PDZ结构域蛋白 (Multi-PDZ domain protein 1)

功能描述

NMDAR信号复合物的成员，可能在兴奋性突触中控制AMPAR增强和突触可塑性方面发挥作用 (PubMed:11150294, PubMed:15312654)。促进HT2RC在细胞表面的聚集 (By similarity)。 {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}。

组织特异性

Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

亚细胞定位

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Synapse. Synapse, synaptosome. Note=Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.