MMP19 Q99542

基质金属蛋白酶-19 (MMP-19) (EC 3.4.24.-) (基质金属蛋白酶 RASI) (基质金属蛋白酶-18) (MMP-18)

功能描述

内肽酶，在发育、止血和病理状况（关节炎疾病）期间降解细胞外基质的多种成分，如聚集蛋白聚糖和软骨寡聚基质蛋白 (comp)。可能也在新血管生成或血管生成中发挥作用。水解IV型胶原、层粘连蛋白、巢蛋白、nascin-C同工型、纤连蛋白和I型明胶。 {ECO:0000269|PubMed:10809722, ECO:0000269|PubMed:10922468}。

组织特异性

Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941).

亚细胞定位

Secreted, extracellular space, extracellular matrix