MKRN2 Q9H000

E3泛素蛋白连接酶makorin-2 (EC 2.3.2.27) (环指蛋白62) (RING型E3泛素转移酶makorin-2)

功能描述

FUNCTION：E3泛素连接酶，催化泛素分子共价附着到底物蛋白上 (By similarity)。促进RELA/p65的多聚泛素化和蛋白酶体依赖的降解，从而抑制RELA介导的NF-kappaB反式激活并负向调控炎症反应 (By similarity)。在精子排放调节和雄性生育力中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q9ERV1}。

组织特异性

Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940). Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen (PubMed:11597136).

亚细胞定位

Cytoplasm