MINAR1 Q9UPX6

主要内在无序Notch2结合受体1 (膜整合NOTCH2相关受体1) (泛素化与mTOR信号蛋白)

功能描述

固有无序蛋白，可能通过稳定mTOR复合体组分DEPTOR来负向调节mTOR信号通路 (PubMed:30080879)。负向调节血管生成 (PubMed:29329397)。负向调节细胞生长 (PubMed:29329397, PubMed:30080879)。负向调节海马神经元神经突生长 (By similarity)。 {ECO:0000250|UniProtKB:D3ZJ47, ECO:0000269|PubMed:29329397, ECO:0000269|PubMed:30080879}。

组织特异性

Widely expressed, including in breast epithelial cells and endothelial cells (at protein level). Expression is down-regulated in advanced breast tumors (at protein level).

亚细胞定位

Cell membrane