MIEN1 Q9BRT3

迁移和侵袭增强子1 (HBV X反式激活基因4蛋白) (HBV XAg反式激活蛋白4) (蛋白C35)

功能描述

通过诱导迁移细胞前缘的丝状伪足形成来增加细胞迁移。参与细胞凋亡的调控，可能通过控制CASP3实现。可能参与氧化还原相关过程。 {ECO:0000269|PubMed:19503095, ECO:0000269|PubMed:21628459}.

组织特异性

Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).

亚细胞定位

Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.