MEX3C Q5U5Q3

RNA结合E3泛素蛋白连接酶MEX3C (EC 2.3.2.27) (含RING指和KH结构域蛋白2) (环指蛋白194) (RING型E3泛素转移酶MEX3C)

蛋白质信息 (UniProt)

RNA结合E3泛素蛋白连接酶MEX3C (EC 2.3.2.27) (含RING指和KH结构域蛋白2) (环指蛋白194) (RING型E3泛素转移酶MEX3C)

Q5U5Q3

功能描述

负责常见HLA-A同种异型转录后调控的E3泛素连接酶。结合HLA-A2 mRNA的3' UTR，并通过促进mRNA衰变来调节其水平。RNA结合足以阻止翻译，但mRNA降解需要泛素连接酶活性。 {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.

组织特异性

Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.

亚细胞定位

Cytoplasm

关键词

3D-structure Cytoplasm Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding Transferase

外部链接

UniProt: Q5U5Q3

NCBI Gene

GeneCards