MCU Q8NE86

线粒体钙单向转运蛋白 (HsMCU) (含卷曲螺旋结构域蛋白109A)

功能描述

线粒体内膜钙单向转运体复合物（uniplex）的成孔和钙传导亚基，介导钙摄取进入线粒体基质 (PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:23755363, PubMed:24332854, PubMed:24560927, PubMed:26341627, PubMed:29954988, PubMed:29995857, PubMed:30454562, PubMed:30638448, PubMed:31080062, PubMed:32494073, PubMed:32762847, PubMed:33296646, PubMed:37036971, PubMed:37126688)。MCU通道活性受uniplex的钙感应亚基MICU1和MICU2（或MICU3）调节 (PubMed:24560927, PubMed:26903221, PubMed:30454562, PubMed:30638448, PubMed:32494073, PubMed:32762847, PubMed:37036971, PubMed:37126688)。线粒体钙稳态在细胞生理学中起关键作用，并调节ATP产生、细胞质钙信号和细胞死亡途径的激活 (PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:23755363, PubMed:24332854, PubMed:24560927, PubMed:26341627, PubMed:29954988, PubMed:32494073, PubMed:32762847)。参与缓冲心肌细胞收缩期钙升高的幅度 (PubMed:22822213)。虽然对于基线稳态心脏功能并非必需，但作为急性应激期间“战斗或逃跑”反应基础上的短期线粒体钙加载的关键调节因子：通过介导起搏细胞中线粒体钙的快速增加起作用 (PubMed:25603276)。参与缺血-再灌注损伤期间的线粒体通透性转换 (By similarity)。骨骼肌细胞中的线粒体钙摄取与成体肌肉大小有关 (By similarity)。调节中枢神经末梢的突触囊泡内吞动力学 (By similarity)。通过调节线粒体钙摄取来调节胰腺β细胞中葡萄糖依赖性的胰岛素分泌 (PubMed:22829870, PubMed:22904319)。参与抗原加工和呈递 (By similarity)。 {ECO:0000250|UniProtKB:Q3UMR5, ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:23755363, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:25603276, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221, ECO:0000269|PubMed:29954988, ECO:0000269|PubMed:29995857, ECO:0000269|PubMed:30454562, ECO:0000269|PubMed:30638448, ECO:0000269|PubMed:31080062, ECO:0000269|PubMed:32494073, ECO:0000269|PubMed:32762847, ECO:0000269|PubMed:33296646, ECO:0000269|PubMed:37036971, ECO:0000269|PubMed:37126688}.

亚细胞定位

Mitochondrion inner membrane