原癌基因 DBL (原癌基因 MCF-2) [切割为：MCF2转化蛋白；DBL转化蛋白]
原癌基因 DBL (原癌基因 MCF-2) [切割为：MCF2转化蛋白；DBL转化蛋白]
P10911功能描述
鸟嘌呤核苷酸交换因子 (GEF)，调节Rho家族GTPase。促进Rho家族GTPase中某些成员从结合GDP形式转化为结合GTP形式。Isoform 1对RHOA、RAC1或CDC42无活性。Isoform 2对CDC42的GEF活性降低。Isoform 3对RAC1和CDC42表现出微弱但显著的活性。Isoform 4对RHOA和CDC42表现出显著活性。截短的DBL癌基因对RHOA、RAC1和CDC42有活性。
组织特异性
Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis.
亚细胞定位
Cytoplasm
关键词