细胞表面糖蛋白 MUC18 (细胞表面糖蛋白 P1H12) (黑色素瘤细胞粘附分子) (黑色素瘤相关抗原 A32) (黑色素瘤相关抗原 MUC18) (S-endo 1 内皮相关抗原) (CD 抗原 CD146)
细胞表面糖蛋白 MUC18 (细胞表面糖蛋白 P1H12) (黑色素瘤细胞粘附分子) (黑色素瘤相关抗原 A32) (黑色素瘤相关抗原 MUC18) (S-endo 1 内皮相关抗原) (CD 抗原 CD146)
P43121功能描述
在细胞粘附以及血管组织细胞间连接处内皮单层的粘聚力中发挥作用。其表达可能允许黑色素瘤细胞与血管系统的细胞成分相互作用，从而增强血源性肿瘤扩散。可能是胚胎发育期间在神经嵴细胞中活跃的粘附分子。作为表面受体发挥作用，触发FYN和PTK2/FAK1的酪氨酸磷酸化，并引起细胞内钙浓度的短暂升高。 {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}。
组织特异性
Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
亚细胞定位
Membrane; Single-pass type I membrane protein.
关键词