Ensconsin (上皮115 kDa微管相关蛋白) (E-MAP-115) (微管相关蛋白7) (MAP-7)
Ensconsin (上皮115 kDa微管相关蛋白) (E-MAP-115) (微管相关蛋白7) (MAP-7)
Q14244功能描述
微管稳定蛋白，在上皮细胞极化和分化过程中微管重组时可能发挥重要作用。以动态方式与微管结合。可能在细胞间接触的形成中发挥作用。与TRPV4共定位导致TRPV4重新分布至细胞膜，并可能连接细胞骨架微丝。 {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
组织特异性
Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.
亚细胞定位
Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
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