MAGEA1 P43355

黑色素瘤相关抗原1 (抗原MZ2-E) (癌/睾丸抗原1.1) (CT1.1) (MAGE-1抗原)

功能描述

可能通过与其SNW1相互作用并招募组蛋白去乙酰化酶HDAC1参与转录调控。可能抑制Notch胞内结构域(NICD)的反式激活。可能在胚胎发育及肿瘤转化或肿瘤进展的某些方面发挥作用。被自体细胞毒性T淋巴细胞识别的黑色素瘤抗原。 {ECO:0000269|PubMed:15316101}。

组织特异性

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.

亚细胞定位

Cytoplasm. Nucleus.