MAFA Q8NHW3

转录因子MafA (胰腺β细胞特异性转录激活因子) (RIPE3b1因子) (V-maf肌腱膜纤维肉瘤癌基因同源物A)

蛋白质信息 (UniProt)

转录因子MafA (胰腺β细胞特异性转录激活因子) (RIPE3b1因子) (V-maf肌腱膜纤维肉瘤癌基因同源物A)

Q8NHW3

功能描述

激活胰岛素基因表达的转录因子 (PubMed:12011435, PubMed:15993959)。与NEUROD1/BETA2和PDX1协同作用 (PubMed:15993959)。结合胰岛素增强子C1/RIPE3b元件 (PubMed:12011435)。结合共有TRE型MARE 5'-TGCTGACTCAGCA-3' DNA序列 (PubMed:23148532, PubMed:29339498)。 {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:23148532, ECO:0000269|PubMed:29339498}。

组织特异性

Expressed in the islets of Langerhans (at protein level).

亚细胞定位

Nucleus

关键词

3D-structure Activator Diabetes mellitus Disease variant DNA-binding Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q8NHW3

NCBI Gene

GeneCards