亮氨酸拉链推定肿瘤抑制因子2 (hLZTS2) (Protein LAPSER1)
亮氨酸拉链推定肿瘤抑制因子2 (hLZTS2) (Protein LAPSER1)
Q9BRK4功能描述
Katanin介导的微管剪切及从中心体释放的负调控因子。为中心纺锤体形成和胞质分裂完成所必需。可能通过阻止微管束的形成来负调控轴突生长，而微管束是伸长轴突内运输所必需的。Wnt信号通路的负调控因子。通过促进beta-catenin的核排斥来抑制beta-catenin介导的转录激活。 {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
组织特异性
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
亚细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
关键词