LZTFL1 Q9NQ48

亮氨酸拉链转录因子样蛋白1

功能描述

调节BBSome复合物的纤毛定位。与BBSome复合物一起，控制SMO的纤毛运输并有助于音猬因子(SHH)通路调节。可能在神经突生长中发挥作用。可能具有肿瘤抑制因子功能。 {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:22510444}.

组织特异性

Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, spleen, small intestine, and peripheral blood leukocytes.

亚细胞定位

Cytoplasm