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LYPD6 Q86Y78

含Ly6/PLAUR结构域蛋白6

蛋白质信息 (UniProt)

含Ly6/PLAUR结构域蛋白6

Q86Y78

功能描述

作为脑内烟碱型乙酰胆碱受体 (nAChRs) 功能的调节因子 (PubMed:27344019, PubMed:34631692)。抑制尼古丁诱导的通过 nAChRs 的 Ca(2+) 内流 (PubMed:27344019)。在体外,以变构方式特异性抑制 alpha-3:beta-4 和 alpha-7 nAChR 电流 (PubMed:34631692)。作为 Wnt/beta-catenin 信号通路的正调节因子 (By similarity)。 {ECO:0000250|UniProtKB:Q66IA6, ECO:0000269|PubMed:27344019, ECO:0000269|PubMed:34631692}。

组织特异性

Detected in the temporal cortex (at protein level) (PubMed:25680266). Ubiquitous (PubMed:19653121). Highly expressed in brain and heart (PubMed:19653121).

亚细胞定位

Secreted

关键词

3D-structure Alternative splicing Cell membrane Cell projection Cytoplasm Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Lipoprotein