LYPD3 O95274

含Ly6/PLAUR结构域蛋白3 (GPI锚定转移相关蛋白C4.4A同源物) (基质胶诱导基因C4蛋白) (MIG-C4)

功能描述

支持细胞迁移。可能参与尿路上皮细胞-基质相互作用。可能参与肿瘤进展。 {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:11245483, ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}.

组织特异性

Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers.

亚细胞定位

Cell membrane; Lipid-anchor, GPI-anchor.