LVRN Q6Q4G3

氨肽酶Q (AP-Q) (APQ) (EC 3.4.11.-) (CHL2抗原) (Laeverin)

功能描述

金属蛋白酶，可能通过调节胚胎-母体界面关键肽的生物活性而对胎盘形成至关重要。在合成底物上，它对 Leu-4-methylcoumaryl-7-amide (Leu-MCA) 表现出明显偏好，优于 Met-MCA、Arg-LCA 和 Lys-LCA。切割多种肽的 N 端氨基酸，例如血管紧张素-3、kisspeptin-10 和 endokinin C。 {ECO:0000269|PubMed:17525158}。

组织特异性

Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level).

亚细胞定位

Membrane