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LST1 O00453

白细胞特异性转录本1蛋白 (Protein B144)

蛋白质信息 (UniProt)

白细胞特异性转录本1蛋白 (Protein B144)

O00453

功能描述

可能在调节免疫应答中发挥作用。在多种细胞类型中过表达时诱导形态学变化,包括丝状伪足和微棘的产生,可能参与树突状细胞成熟。Isoform 1和isoform 2对淋巴细胞增殖具有抑制作用。{ECO:0000269|PubMed:10706707, ECO:0000269|PubMed:11478849}。

组织特异性

Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.

亚细胞定位

Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.

关键词

Alternative splicing Cell shape Golgi apparatus Immunity Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix