脂肪瘤优先伴侣 (脂肪瘤中含LIM结构域的优先易位伴侣)
脂肪瘤优先伴侣 (脂肪瘤中含LIM结构域的优先易位伴侣)
Q93052功能描述
可能在细胞粘附位点发挥结构作用，以维持细胞形状和运动能力。除了这些结构功能外，它还可能参与信号事件和基因转录的激活。可能参与从细胞粘附位点到细胞核的信号转导，从而成功整合来自可溶性因子和细胞-细胞粘附位点的信号。也有观点认为其作为支架蛋白，在细胞质和细胞核中组装不同的蛋白复合物。 {ECO:0000269|PubMed:10637295}。
组织特异性
Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
亚细胞定位
Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.
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