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LIPA P38571

溶酶体酸性脂肪酶/胆固醇酯水解酶 (酸性胆固醇酯水解酶) (LAL) (EC 3.1.1.13) (胆固醇酯酶) (二酰甘油脂肪酶) (脂肪酶A) (固醇酯酶) (三酰甘油酯水解酶) (三酰甘油脂肪酶)

蛋白质信息 (UniProt)

溶酶体酸性脂肪酶/胆固醇酯水解酶 (酸性胆固醇酯水解酶) (LAL) (EC 3.1.1.13) (胆固醇酯酶) (二酰甘油脂肪酶) (脂肪酶A) (固醇酯酶) (三酰甘油酯水解酶) (三酰甘油脂肪酶)

P38571

功能描述

催化内吞的低密度脂蛋白的胆固醇酯核心脂质的脱酰基作用,生成游离脂肪酸和胆固醇 (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed:8112342, PubMed:9633819)。水解甘油三酯 (1,2,3-三酰甘油) 和甘油二酯 (如1,2-二酰甘油和1,3-二酰甘油),优先水解sn-1或sn-3位的酰基部分 (PubMed:7204383, PubMed:8112342)。 {ECO:0000269|PubMed:15269241, ECO:0000269|PubMed:1718995, ECO:0000269|PubMed:7204383, ECO:0000269|PubMed:8112342, ECO:0000269|PubMed:9633819, ECO:0000305|PubMed:15269241, ECO:0000305|PubMed:8112342}。

组织特异性

Most abundantly expressed in brain, lung, kidney and mammary gland, a moderate expression seen in placenta and expressed at low levels in the liver and heart.

亚细胞定位

Lysosome

关键词

3D-structure Alternative splicing Direct protein sequencing Disease variant Glycoprotein Hydrolase Lipid degradation Lipid metabolism Lysosome Proteomics identification