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LANCL1 O43813

谷胱甘肽S-转移酶 LANCL1 (EC 2.5.1.18) (40 kDa红细胞膜蛋白) (p40) (LanC样蛋白1)

蛋白质信息 (UniProt)

谷胱甘肽S-转移酶 LANCL1 (EC 2.5.1.18) (40 kDa红细胞膜蛋白) (p40) (LanC样蛋白1)

O43813

功能描述

具有谷胱甘肽转移酶功能。催化谷胱甘肽 (GSH) 与人工底物1-氯-2,4-二硝基苯 (CDNB) 及对硝基苯乙酸酯的结合。可能通过GSH抗氧化防御机制,在正常出生后发育过程中及响应氧化应激时减轻神经元氧化应激 (By similarity)。可能在EPS8信号传导中发挥作用。结合谷胱甘肽 (PubMed:19528316)。 {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}。

组织特异性

Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation Cell membrane Cytoplasm Direct protein sequencing Membrane Metal-binding Proteomics identification Reference proteome Transferase