KRT19 P08727

I型细胞骨架角蛋白19 (细胞角蛋白-19) (CK-19) (角蛋白-19) (K19)

功能描述

参与肌纤维的组织。与KRT8一起，帮助将收缩装置连接到横纹肌肋节的肌营养不良蛋白。 {ECO:0000269|PubMed:16000376}。

组织特异性

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.