KLRC2 P26717

NKG2-C II型整合膜蛋白 (CD159抗原样家族成员C) (NK细胞受体C) (NKG2-C激活型NK受体) (CD抗原CD159c)

功能描述

参与自身-非自身辨别的免疫激活受体。在细胞毒性淋巴细胞亚群上与KLRD1形成复合物，识别负载有来自非经典MHC I类分子HLA-G信号序列衍生肽的非经典主要组织相容性（MHC）I类分子HLA-E，可能在适应性自然杀伤（NK）细胞的生成和效应功能以及妊娠期间的母胎耐受中发挥作用（PubMed:30134159, PubMed:37264229, PubMed:9754572）。调节终末分化的细胞毒性淋巴细胞亚群的效应功能，特别是在适应性NK细胞对病毒感染的反应中可能发挥作用（PubMed:20952657, PubMed:21825173）。在HLA-E-肽结合后，通过接头蛋白TYROBP/DAP12传递细胞内信号，触发近端信号分子的磷酸化和细胞活化（PubMed:15940674, PubMed:9655483）。 {ECO:0000269|PubMed:15940674, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9655483, ECO:0000269|PubMed:9754572}。

组织特异性

Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level) (PubMed:20952657, PubMed:21825173). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:20952657). Expressed in alpha-beta T cells subsets (at protein level) (PubMed:20952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed within NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657).

亚细胞定位

Cell membrane