KLK6 Q92876

激肽释放酶-6 (EC 3.4.21.-) (神经素) (蛋白酶 M) (SP59) (丝氨酸蛋白酶 18) (丝氨酸蛋白酶 9) (酶)

功能描述

功能：丝氨酸蛋白酶，对底物P1位置的Arg（精氨酸）偏好性高于Lys（赖氨酸），对P2位置的Ser（丝氨酸）或Pro（脯氨酸）具有偏好性。对淀粉样前体蛋白、髓鞘碱性蛋白、明胶、酪蛋白以及细胞外基质蛋白（如纤连蛋白、层粘连蛋白、玻连蛋白和胶原蛋白）显示出活性。降解α-突触核蛋白并阻止其聚合，表明其可能参与帕金森病和其他突触核蛋白病的发病机制。可能参与脊髓损伤后轴突生长的调节。用KLK6中和抗体处理的肿瘤细胞迁移少于对照细胞，提示其在侵袭和转移中具有作用。 {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}。

组织特异性

In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.

亚细胞定位

Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.