KLK14 Q9P0G3

激肽释放酶-14 (hK14) (EC 3.4.21.-) (激肽释放酶样蛋白 6) (KLK-L6)

功能描述

具有双重胰蛋白酶样和胰凝乳蛋白酶样底物特异性的丝氨酸型内肽酶。可能激活/灭活蛋白酶激活受体F2R、F2RL1和F2RL3以及其他激肽释放酶，包括KLK1、KLK3、KLK5和KLK11。可能通过直接切割精液凝胶蛋白SEMG1和SEMG2以及激活KLK3在精液凝块液化中发挥作用。可能通过切割桥粒芯蛋白DSG1在表皮脱屑中发挥作用，该过程是最浅表层角质形成细胞从皮肤表面脱落的过程。可能参与肿瘤进展的多个方面，包括生长、侵袭和血管生成。{ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16885167, ECO:0000269|PubMed:17158887, ECO:0000269|PubMed:17625593, ECO:0000269|PubMed:18056261, ECO:0000269|PubMed:18482984}。

组织特异性

Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level).

亚细胞定位

Secreted, extracellular space