KIF2C Q99661

驱动蛋白样蛋白 KIF2C (驱动蛋白样蛋白 6) (有丝分裂着丝粒相关驱动蛋白) (MCAK)

功能描述

与KIF18B形成复合物，构成有丝分裂细胞中主要的微管正端解聚活性 (PubMed:21820309)。调节动粒处微管的周转，并在有丝分裂过程中发挥染色体分离功能 (PubMed:19060894)。在染色体整列中发挥作用，并且是染色体-微管附着从侧向转为端向所必需的 (PubMed:23891108)。 {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}。

组织特异性

Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.

亚细胞定位

Cytoplasm, cytoskeleton