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KIF12 Q96FN5

驱动蛋白样蛋白 KIF12

蛋白质信息 (UniProt)

驱动蛋白样蛋白 KIF12

Q96FN5

功能描述

参与脂肪酸生物合成的负调控,可能作为适配体,允许E3泛素-蛋白连接酶COP1对乙酰辅酶A羧化酶1 (ACACA)进行泛素化,并促进ACACA降解 (PubMed:39920308)。该适配体功能需要C末端富含脯氨酸结构域,且可能与驱动蛋白马达活性无关 (Probable)。 {ECO:0000269|PubMed:39920308, ECO:0000305|PubMed:39920308}。

组织特异性

Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer.

亚细胞定位

Cytoplasm, cytoskeleton

关键词

ATP-binding Cell projection Coiled coil Cytoplasm Cytoskeleton Disease variant Intrahepatic cholestasis Microtubule Motor protein Nucleotide-binding