3-酮基二氢鞘氨醇还原酶 (KDS还原酶) (EC 1.1.1.102) (3-脱氢鞘氨醇还原酶) (滤泡变异易位蛋白1) (FVT-1) (短链脱氢酶/还原酶家族35C成员1)
3-酮基二氢鞘氨醇还原酶 (KDS还原酶) (EC 1.1.1.102) (3-脱氢鞘氨醇还原酶) (滤泡变异易位蛋白1) (FVT-1) (短链脱氢酶/还原酶家族35C成员1)
Q06136功能描述
催化3'-氧鞘氨醇（3-酮二氢鞘氨醇/KDS）还原为鞘氨醇（二氢鞘氨醇/DHS），这是鞘脂从头合成的第二步。 {ECO:0000269|PubMed:19141869, ECO:0000269|PubMed:28575652, ECO:0000269|PubMed:28774589, ECO:0000269|PubMed:34373586, ECO:0000269|PubMed:36170811}.
组织特异性
Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes.
亚细胞定位
Endoplasmic reticulum membrane
关键词