KCTD12 Q96CX2

含BTB/POZ结构域蛋白KCTD12 (Pfetin) (主要胎儿表达T1结构域)

功能描述

GABA-B受体的辅助亚基，决定受体反应的药理学和动力学特性。提高激动剂效力，并通过加速起效和促进脱敏显著改变受体的G蛋白信号传导（通过相似性）。{ECO:0000250}。

组织特异性

Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.

亚细胞定位

Presynaptic cell membrane. Postsynaptic cell membrane