KCNK6 Q9Y257

钾通道亚家族K成员6 (内向整流钾通道蛋白TWIK-2) (TWIK起源相似序列)

功能描述

K(+)通道，在内溶酶体系统膜上介导外向整流电流 (PubMed:10887187, PubMed:28381826)。在溶酶体中具有活性，调节溶酶体的数量和大小 (PubMed:28381826)。在巨噬细胞中，介导与细菌感染后ATP诱导的NLRP3炎症小体激活相偶联的K(+)外流。与ATP门控P2RX7通道协同激活NLRP3炎症小体，其中P2RX7介导Ca(2+)和Na(+)内流，为K(+)外流设定膜电位 (By similarity)。 {ECO:0000250|UniProtKB:Q3TBV4, ECO:0000269|PubMed:10887187, ECO:0000269|PubMed:28381826}.; FUNCTION: [Isoform 2]: 不显示通道活性。 {ECO:0000269|PubMed:10887187}.

组织特异性

Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

亚细胞定位

Late endosome membrane