KCNK1 O00180

钾通道亚家族K成员1 (内向整流钾通道蛋白TWIK-1) (钾通道 K2P1) (钾通道 KCNO1)

功能描述

离子通道，参与脑星形胶质细胞以及肾脏和其他组织中的被动跨膜钾转运和静息膜电位调节 (PubMed:15820677, PubMed:21653227)。形成二聚体通道，钾离子根据其电化学梯度通过该通道。在生理钾浓度和中性pH下，该通道对K(+)离子具有选择性，但在低于生理水平的K(+)浓度下以及细胞外介质酸化时，对Na(+)具有通透性 (PubMed:21653227, PubMed:22431633)。同源二聚体在异源表达系统中具有极低的钾通道活性，并可作为弱内向整流钾通道发挥作用 (PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086, PubMed:8605869, PubMed:8978667)。通道活性受血清素受体激活的调节 (By similarity)。包含KCNK1和KCNK2的异源二聚体通道具有高得多的活性，可能代表星形胶质细胞中的主要形式 (By similarity)。包含KCNK1和KCNK3或KCNK9的异源二聚体通道具有高得多的活性 (PubMed:23169818)。由KCNK1和KCNK9形成的异源二聚体通道可能有助于氟烷敏感电流 (PubMed:23169818)。介导齿状回颗粒细胞中的外向整流钾电流，并有助于调节其静息膜电位 (By similarity)。有助于调节齿状回颗粒细胞中的动作电位发放，并下调其内在兴奋性 (By similarity)。在星形胶质细胞中，由KCNK1和KCNK2形成的异源二聚体是响应G蛋白偶联受体（如F2R和CNR1）激活快速释放谷氨酸所必需的 (By similarity)。是肾脏正常离子和水转运所必需的 (By similarity)。有助于调节胰腺β细胞的静息膜电位 (By similarity)。同源二聚体KCNK1的低通道活性可能归因于SUMO化 (PubMed:15820677, PubMed:20498050, PubMed:23169818)。低通道活性可能归因于从细胞膜快速内化并滞留在循环内体中 (PubMed:19959478)。对单价阳离子具有通透性，离子选择性为K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+)。 {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:19959478, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}.

组织特异性

Detected in bronchial epithelial cells (PubMed:21964404). Detected in heart left atrium and left ventricle (PubMed:17478540). Detected in cardiac myocytes (at protein level) (PubMed:21653227). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed:8605869, PubMed:9362344). Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed:11165377). Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed:17478540).

亚细胞定位

Cell membrane