A型电压门控钾通道 KCND3 (钾电压门控通道亚家族D成员3) (电压门控钾通道亚基 Kv4.3)
A型电压门控钾通道 KCND3 (钾电压门控通道亚家族D成员3) (电压门控钾通道亚基 Kv4.3)
Q9UK17功能描述
电压门控A型钾通道的成孔（alpha）亚基，介导大脑和心脏可兴奋膜中的跨膜钾转运 (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794)。在心肌细胞中，可能产生瞬时外向钾电流I(To) (By similarity)。在神经元中，可能传导瞬时阈下胞体树突A型钾电流(ISA) (By similarity)。动力学特征表现为阈下膜电位的快速激活、快速失活以及失活后的快速恢复 (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794)。通道特性受与调节亚基相互作用的调节 (PubMed:17187064, PubMed:34997220)。与调节亚基KCNIP1或KCNIP2相互作用可调节通道门控动力学，即通道激活和失活动力学以及失活恢复速率 (PubMed:17187064, PubMed:34997220)。同样，与DPP6相互作用可调节通道门控动力学，即通道激活和失活动力学 (PubMed:34997220)。 {ECO:0000250|UniProtKB:Q62897, ECO:0000269|PubMed:10200233, ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:21349352, ECO:0000269|PubMed:22457051, ECO:0000269|PubMed:23280837, ECO:0000269|PubMed:23280838, ECO:0000269|PubMed:34997220, ECO:0000269|PubMed:9843794}。
组织特异性
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus (PubMed:10200233, PubMed:10729221, PubMed:9843794). Detected at lower levels in liver, skeletal muscle, kidney and pancreas (PubMed:10200233, PubMed:10729221).
亚细胞定位
Cell membrane
关键词