KCNAB2 Q13303

电压门控钾通道β2亚基 (EC 1.1.1.-) (K(+)通道β2亚基) (Kv-beta-2) (hKvbeta2)

功能描述

电压门控钾 (Kv) Shaker通道的调节亚基，由成孔且传导钾离子的alpha亚基和调节性beta亚基组成 (PubMed:11825900, PubMed:7649300)。beta-2/KCNAB2胞质亚基通过一种不涉及通道孔物理阻塞的机制促进钾通道关闭 (PubMed:11825900, PubMed:7649300)。促进含有Kv1.4/KCNA4和Kv1.5/KCNA5 alpha亚基的通道失活 (PubMed:11825900, PubMed:7649300)。通过催化多种醛和酮底物的NADPH依赖性还原，显示烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 依赖性的醛酮还原酶活性 (By similarity)。底物特异性包括甲基乙二醛、9,10-菲醌、前列腺素J2、4-硝基苯甲醛、4-硝基苯乙酮和4-氧代-反式-2-壬烯醛（体外实验，尚未鉴定出生理底物） (By similarity)。氧化型和还原型核苷酸的结会改变Kv通道门控，并可能有助于动态精细调节细胞兴奋性 (By similarity)。有助于调节神经信号传导，并防止神经元过度兴奋 (By similarity)。 {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}。

组织特异性

Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300).

亚细胞定位

Cytoplasm