JAG1 P78504

锯齿蛋白1 (Jagged1) (hJ1) (CD抗原 CD339)

功能描述

多个Notch受体的配体，参与介导Notch信号传导 (PubMed:18660822, PubMed:20437614)。可能参与造血过程中的细胞命运决定 (PubMed:9462510)。似乎参与哺乳动物心血管发育的早期和晚期阶段。抑制成肌细胞分化 (By similarity)。增强成纤维细胞生长因子诱导的血管生成 (in vitro)。 {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:20437614, ECO:0000269|PubMed:9462510}。

组织特异性

Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

亚细胞定位

Membrane; Single-pass type I membrane protein. Cell membrane