ITSN1 Q15811

intersectin-1 (含SH3结构域蛋白1A) (SH3P17)

功能描述

作为适配蛋白，连接内吞膜运输和肌动蛋白组装机制 (PubMed:11584276, PubMed:29887380)。作为CDC42的鸟苷酸交换因子 (GEF)，从而刺激由WASL和ARP2/3复合物介导的肌动蛋白成核 (PubMed:11584276)。在网格蛋白包被囊泡的组装和成熟过程中起作用 (By similarity)。将FCHSD2募集到网格蛋白包被凹陷处 (PubMed:29887380)。参与激活的EGFR的内吞，可能也参与其他生长因子受体的内吞 (By similarity)。参与整合素beta-1 (ITGB1) 和转铁蛋白受体 (TFR) 的内吞；ITGB1作为DAB2依赖性货物的内吞（而非TFR）可能涉及与DAB2的关联 (PubMed:22648170)。促进EGFR的泛素化及随后的降解，从而有助于EGFR依赖性信号通路的下调。在嗜铬细胞中，是儿茶酚胺正常胞吐所必需的。是突触前活性区释放准备就绪的突触囊泡快速补充所必需的 (By similarity)。抑制ARHGAP31对RAC1的活性 (PubMed:11744688)。 {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: 在脑神经元突触囊泡内吞中发挥作用。 {ECO:0000250|UniProtKB:Q9Z0R4}.

组织特异性

Isoform 1 is expressed almost exclusively in the brain. Isoform 2 is detected in brain, spleen, lung, liver, heart, skeletal muscle and kidney. Isoform 5 is primarily expressed in brain, spleen, lung and kidney (at protein level) (PubMed:21712076). Isoform 1 and isoform 2 are detected in brain (PubMed:10482960). Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord (PubMed:11690630, PubMed:21712076, PubMed:9799604).

亚细胞定位

Endomembrane system