ITGA6 P23229

整合素α-6 (CD49抗原样家族成员F) (VLA-6) (CD抗原CD49f) [切割为：整合素α-6重链；整合素α-6轻链；加工的整合素α-6 (Alpha6p)]

功能描述

整合素alpha-6/beta-1 (ITGA6:ITGB1) 是血小板中层粘连蛋白的受体 (By similarity)。整合素alpha-6/beta-1 (ITGA6:ITGB1) 存在于卵母细胞中，并参与精子-卵子融合 (By similarity)。整合素alpha-6/beta-4 (ITGA6:ITGB4) 是上皮细胞中层粘连蛋白的受体，并在半桥粒中发挥关键的结构作用 (By similarity)。ITGA6:ITGB4 结合 NRG1 (通过 EGF 结构域)，这种结合对于 NRG1-ERBB 信号传导至关重要 (PubMed:20682778)。ITGA6:ITGB4 结合 IGF1，这种结合对于 IGF1 信号传导至关重要 (PubMed:22351760)。ITGA6:ITGB4 结合 IGF2，这种结合对于 IGF2 信号传导至关重要 (PubMed:28873464)。 {ECO:0000250|UniProtKB:Q61739, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}。

组织特异性

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Processed integrin alpha-6: Expressed at low levels in normal prostate tissue with elevated levels in prostate cancer tissue (at protein level) (PubMed:15023541).

亚细胞定位

Cell membrane