IL34 Q6ZMJ4

白细胞介素-34 (IL-34)

功能描述

促进单核细胞和巨噬细胞增殖、存活和分化的细胞因子。促进促炎趋化因子的释放，从而在先天免疫和炎症过程中发挥重要作用。在破骨细胞增殖和分化的调节以及骨吸收的调节中发挥重要作用。通过CSF1R及其下游效应因子的信号传导刺激MAPK1/ERK2和MAPK3/ERK1的磷酸化。 {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}。

组织特异性

Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

亚细胞定位

Secreted