IL31RA Q8NI17

白细胞介素-31受体亚基α (IL-31受体亚基α) (IL-31R亚基α) (IL-31R-α) (IL-31RA) (细胞因子受体样3) (GLM-R) (hGLM-R) (Gp130样单核细胞受体) (Gp130样受体) (ZcytoR17)

功能描述

与OSMR结合形成白细胞介素-31受体，该受体激活STAT3，并在较低程度上激活STAT1和STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15194700, PubMed:15627637)。可能在皮肤免疫中发挥作用 (PubMed:15184896)。介导IL31诱导的瘙痒，可能以依赖阳离子通道TRPA1和TRPV1的方式 (By similarity)。在体内正向调节骨髓中未成熟髓系祖细胞亚群的数量和周期状态，并在体外增强髓系祖细胞的存活 (By similarity)。 {ECO:0000250|UniProtKB:Q8K5B1, ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15627637}。

组织特异性

Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:11877449, PubMed:14504285, PubMed:15184896). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).

亚细胞定位

Cell membrane